Epi proColon® is a minimally invasive blood test for colorectal cancer screening for patients who are unwilling or unable to be screened by recommended methods. It is the first FDA Approved molecular DNA blood test for colorectal cancer screening. The test detects methylated Septin 9 DNA, a differential blood biomarker that is methylated in colorectal cancer. Epi proColon detects cell-free tumor DNA circulating in blood. The proprietary Septin 9 gene methylation biomarker is extracted from plasma by enhanced sensitive nucleic acid isolation, followed by bisulfite conversion, real-time PCR and analysis. The test can be performed in any high complexity clinical laboratory.