AB ANALITICA SRL

VIA SVIZZERA 16
PADOVA,  35127

Italy
https://www.abanalitica.com/en/home-en/

• Booth: 4953

 Press Releases

• REALQUALITY Carba-Screen (Apr 11, 2024)

  The REALQUALITY Carba-Screen kit is indicated for the screening and identification of the main Ambler classes A, B and D carbapenemases responsible for resistance to carbapenem antibiotics and colistin resistance genes by Real-Time PCR.

  Product Characteristics

  • The assay requires only 5 µL of DNA extracted
  • The kit allows the screening and identification of the main Ambler classes A, B and D carbapenemases responsible for resistance to carbapenem antibiotics and colistin resistance genes by using three different mixes:
    • Carba-Screen Real time mix identifies positive samples for A or D and B carbapenemases classes and for the Acinetobacter OXA genes
    • Carba A+D Real time mix identifies the resistance genes belonging to A (KPC) and D (OXA-48 like), and the co-presence of genes associated with colistin resistance (MCR 1, 2, 4)
    • Carba B Real time mix identifies the resistance genes belonging to B class (IMP, VIM, NDM)
  • Validated on main Real-Time PCR instruments
  • The assay includes dUTP/UNG system for preventing carry-over contamination
  • The automatic format of the assay can be used on GENEQUALITY^® automatic platforms

  Kit content

  Kit content:

  Further Information

  Antimicrobial resistance is a growing health problem worldwide. The World Health Organization has included among its most critical priorities the development of new antibacterial agents for the treatment of Enterobacteriaceae resistant to carbapenems (CRE), as this type of resistance has minimized the usefulness of many commercially available drugs, limiting the therapeutic options available.

  The main mechanism of resistance to carbapenems is based on the production of the carbapenemase enzyme, that is able to hydrolyze carbapenems and other β-lactam antibiotics. The encoding genes for this enzyme are associated with plasmids and therefore horizontally transferable and they are included in three of the four classes of β-lactamases (A, B and D), according to the Ambler classification.

  KPC class A enzymes are currently the predominant carbapenemases reported worldwide among Enterobacteriaceae. VIM, IMP and NDM are the most geographically widespread metallo-β-lactamases. As for class D carbapenemases, OXA-48-like carbapenemases are the most common among Enterobacteriaceae.

  Together with CRE, Acinetobacter baumannii is considered as one of the main hospital-acquired pathogens capable of resisting the main antimicrobials and surviving in the healthcare environment. OXA-type carbapenemases constitute the most widespread mechanism of resistance to carbapenems in this species.

  Another resistance that has emerged in recent years is colistin resistance, which is considered a problem due to the lack of alternative antibiotics. Some bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, and members of Enterobacteriaceae, such as E. coli, Salmonella spp. and Klebsiella spp. have acquired resistance to colistin. Colistin is an effective antibiotic for the treatment of most multidrug-resistant Gram-negative bacteria. Horizontal transfer of colistin resistance is given by mcr genes.

  • Ready-to-use reagents for Real-Time PCR
  • Positive control (one or more, depending on the device variant):
    • PC Carba-Screen
    • PC Carba A+D
    • PC Carba B

• REALQUALITY CANDIDA PLUS (Apr 11, 2024)

  The REALQUALITY Candida Plus is indicated for the qualitative detection of the DNA of Candida albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. auris and Candida spp. by Real-Time PCR.

  Product Characteristics

  • The device is validated on DNA extracted from various samples types
  • The kit allows detection of the main pathogenically relevant Candida species by using two ready-to-use reaction mix:
  • Candida Real time mix 1 detect C. albicans, C. glabrata, C. krusei and the internal control β-globin. 
  • Candida Real time mix 2 detect C. parapsilosis, C. tropicalis, C. auris e Candida spp.
  • The assay requires only 5 µL of DNA extracted
  • The assay includes dUTP/UNG system for preventing carry-over contamination and a fluorescence normalizer
  • The automatic format of the assay can be used on GENEQUALITY® automatic platforms
  • Easy interpretation of results with AB Genius Report software

  Kit content

  The kit includes:

  • Ready-to-use reagents for Real-Time PCR 
  • Internal control
  • Positive control

  Further Information

  The Candida genus includes a variety of microorganisms, normally commensal of human mucous membranes. More than 200 species are recognized, however, only 10% are classified as pathogenic to humans. Microorganisms of the Candida genus can cause superficial infections, which can involve the mucous membranes, the skin and in the most serious cases also invasive systemic infections characterized by high mortality. At the hospital level, patients admitted in intensive therapies, immunosuppressed patients, suffering from neutropenia are at high risk of developing invasive candidiasis.

  The scenario of symptoms and clinical signs in cases of candidiasis is broad and varied and may be non-specific. Providing rapid treatment with the correct antifungal is essential. Given the different resistance patterns, mostly species-specific, rapid identification of the species is crucial to choose the most suitable antifungal in case data on antimicrobial susceptibility are not available.

• REALQUALITY ASPERGILLUS (Apr 11, 2024)

  The REALQUALITY Aspergillus kit is indicated for qualitative DNA detection of the DNA of Aspergillus fumigatus, Aspergillus terreus and Aspergillus spp. by Real-Time PCR.

  Product Characteristics

  • The device is validated on DNA extracted from various samples types
  • The assay requires only 5 µL of DNA extracted
  • The assay includes dUTP/UNG system for preventing carry-over contamination and a fluorescence normalizer
  • The automatic format of the assay can be used on GENEQUALITY^® automatic platforms
  • Easy interpretation of results with AB Genius Report software

  Kit content

  • Ready-to-use reagents for Real-Time PCR 
  • Internal control 
  • Positive control

  Further Information

  The Aspergillus genus includes ubiquitous filamentous fungi commonly present in various environments, both outdoors and indoors. Of the over 250 known Aspergillus species, fewer than 40 are of clinical interest. The main route of infection in humans occurs through inhalation of spores produced by the fungus. Allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis are the most common infections caused by this pathogen and mainly affect patients with asthma or cystic fibrosis. Invasive aspergillosis, less frequent, is found in immunocompromised patients and can lead to infections with high mortality and morbidity rates. Treatment varies depending on the type of aspergillosis and may include the use of antifungal drugs or the need for surgery.

  The main etiological agent of aspergillosis is Aspergillus fumigatus. However, other Aspergillus species are emerging as pathogens that can also cause severe invasive infections, including A. terreus, which is particularly resistant to antifungals used in aspergillosis therapies, as well as A. flavus, A. glaucus, A. nidulans, A. niger, and A. ustus. A rapid, accurate and reliable diagnosis is essential for an appropriate treatment plan, allowing to reduce the time spent in intensive care units and increase survival rates.

• GENEQUALITY® 2050 (Apr 11, 2024)

  The GENEQUALITY^® TWENTYFIFTY (GQ 2050) is an automated sample-to-result system, with integrated thermal cycler, for the extraction of nucleic acids from biological samples, the Real-Time PCR reactions set-up and run and the reporting of the results.

  Product Characteristics

  • Extraction of DNA and RNA from different matrices in the same analytical run, starting from the primary tube.
  • Quick extraction system with magnetic rod system.
  • Full traceability of the entire workflow.
  • Software with touch screen interface configurable in different languages.
  • Decontamination control with the integrated UV lamp.
  • Bidirectional interface to the laboratory management system.
  • Up to 32 biological samples processed simultaneously from primary tubes.
  • Sample carriers capable of accommodating primary tubes with diameters from 11 to 16 mm and heights from 65 to 105 mm.
  • Up to 24 different Real-Time PCR reactions.
  • Active cooling block for Real-Time PCR reagents.
  • Software for automatic processing of Real-Time PCR data.

  Further Information

  The system presents several control and safety features including:+

  • 1 air displacement channel with volume range up to 1000 μL, barometric and capacitive liquid sensor, and clot detection;
  • Control of heating block temperatures;
  • A camera system that assists the operator during the instrument loading.

  Additionally, the GQ 2050 is equipped with a Hepa filter for environmental safety, UV lamp and tips with filters to manage and limit potential contaminations.

• REALQUALITY RQ-Multi HPV Detection (Apr 11, 2024)

  The REALQUALITY RQ-Multi HPV Detection kit is an IVD for detection of the DNA of 14 high-risk, 6 possibly high-risk and 8 low-risk genotypes of the Human Papillomavirus (HPV) and genotyping of HPV 16 and HPV 18 by Real-Time PCR.

  Product Characteristics

  • The device is validated on DNA extracted from various sample types;
  • The assay requires only 5 µL of DNA extracted;
  • The kit allows the detection of 14 high-risk genotypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68), 6 possibly high-risk genotypes (HPV 26, 53, 67, 70, 73, 82) and 8 low-risk genotypes (HPV 6, 11, 40, 42, 43, 44, 55, 83) of Human Papillomavirus in two reactions;
  • The kit is able to specifically identify the HPV 16 and HPV 18 genotypes;
  • The assay shares the same thermal profile of the REALQUALITY Infectious diseases kits and the REALQUALITY STI kits;
  • Validated on main Real-Time PCR instruments;
  • The assay includes dUTP/UNG system for preventing carry-over contamination and a fluorescence normalizer;
  • The automatic format of the assay can be used on GENEQUALITY® platform
  • Easy interpretation of results with AB Genius Report software.

  Kit content

  The kit includes:

  • Ready-to-use reagents for Real-Time PCR
  • Internal control
  • Positive control

  Further Information

  Human Papillomavirus (HPV) infection is the most common and widespread of sexually transmitted diseases. The different types of HPV are generally divided into low-risk and high-risk cancer risk genotypes. The latter (in particular HPV 16 and 18) are recognized as the necessary cause of cervical cancer and, in general, among the most important carcinogenic viruses for the human species. The transforming role, in fact, does not end in genesis of the cervical carcinoma, but it is strongly correlated to other neoplasms of the female and male genital sphere (vulva, vagina, anus, penis) and extragenital neoplasms (oral cavity, pharynx, larynx). The carcinogenic potentials can be ascribed to two viral oncoproteins (E6 and E7) which, after the integration of the viral genome into the host genome, cause an uncontrolled proliferative stimulus. This leads to a decrease capability in controlling the cellular surveillance mechanisms, with consequent accumulation of genetic abnormalities, increased genomic instability and the appearance of aneuploidy.
  During the process of viral integration, part of the HPV DNA may be lost. However, this process never involves the E6 and E7 genes, so using a screening system targeting those genes exclude the possibility of false negative results due to viral integration events.