The ECD Global Alliance is dedicated to the awareness, support, education, and research related to Erdheim-Chester Disease (ECD). ECD is an ultra-rare type of blood cancer that is difficult to diagnose and can manifest in a variety of complex ways. Hematologists, together with other clinicians, pathologists, and radiologists, play a vital role in identifying ECD. There are viable FDA-approved and off-label treatments available to improve the quality of life and slow the progression of the life-threatening disease. The key to a successful or more positive outcome is early diagnosis.