Large-scale validated antibodies for immunohistochemistry

MS Validated Antibodies

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Unique documentation of antibody performance including more than 70 images for every product
MSVA offers highly specific antibodies for immunohistochemistry
All MSVA antibodies are validated for IHC on TMA's containing 76 different normal tissues and numerous cancer tissue types

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The enzyme S-methyl-5′-thioadenosine phosphorylase (MTAP) is of topical interest because its inactivation by homozygous 9p21.3 deletion occurs commonly in cancer and offers several new therapeutic and diagnostic options. Because of its pivotal position in the salvage pathway for adenine synthesis, synthetic lethality occurs in MTAP deficient cancer cells if these are exposed to drugs targeting PRMT5, MATA2, or enzymes of “de novo” adenine synthesis. Because MTAP is ubiquitously expressed, a homozygous deletion of the MTAP gene results in a complete expression loss which is detectable by IHC. In surgical pathology, a complete MTAP negativity by IHC is considered a surrogate for a homozygous 9p21 deletion and viewed as a marker for neoplastic transformation in case of cancer-suspicious mesothelial, urothelial, or other cells.

To systematically assess the prevalence of MTAP deficiency in different cancer types, and to assess the diagnostic utility of MTAP IHC, researchers from the University of Hamburg have now successfully analyzed 13’067 tumors from 149 different tumor categories for MTAP expression in formalin fixed archival tissues[1]. They used our antibody MSVA-741R which was thoroughly validated on 76 different normal tissue types by comparison with an independent second antibody and RNA expression data.

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