Biological Industries USA  

NutriStem® hPSC XF Medium is a widely published, defined, xeno-free, serum-free cell culture medium designed to support the growth and expansion of human induced pluripotent stem (hiPS) and human embryonic stem (hES) cells. Protocols have been established around the world for applications ranging from derivation to differentiation. NutriStem® hPSC XF Medium offers the ability to culture cells in a completely xeno-free medium without the need for high levels of basic FGF and other stimulatory growth factors and cytokines. NutriStem® hPSC XF Medium exhibits a consistent media performance and predictable cellular behavior derived from a defined xeno-free formulation as well as increased reproducibility shown in long-term growth of over 50 passages.

• Defined, serum-free, and xeno-free 
• Flexible and compatible with multiple matrices
• Amenable to weekend-free culture
• FDA Drug Master File (DMF) available, produced under cGMP
• Enables efficient expansion and growth of hES and hiPS cells in feeder-free culture systems
• Extensively tested and widely used on multiple hES and iPS cell lines, including H1, H9.2, I6, I3.2, and CL1

Faster growth rates and stronger cell yields

MSC NutriStem® XF Medium is a defined, serum-free, xeno-free culture medium designed for optimal growth and expansion of human mesenchymal stem/stromal cells (hMSC) derived from a variety of sources, including bone marrow (BM-MSC), adipose tissue (AT-MSC) and umbilical cord matrix (UC-MSC). MSC NutriStem® XF Medium supports long-term growth of hMSC while maintaining their self-renewal and multi-lineage differentiation potential.

hMSCs cultured in MSC NutriStem XF Medium show superior proliferation and self-renewal potential in comparison to serum-containing media and other commercial serum-free media.  In addition, hMSCs maintain their proper fibroblast-like cell morphology, tri-lineage differentiation potential, and demonstrate normal hMSC marker profiles, and karyotypic stability over long-term culture. 

Key advantages

• Serum-free, xeno-free, defined culture system
• Superior cell growth compared to serum-containing media
• Supports long-term growth and self-renewal of hMSCs from multiple sources
• Consistent, reliable MSC cultures
• Eliminates the need to spend time and money pre-qualifying FBS lots
• Manufactured under cGMP
• FDA Drug Master File (DMF) available

Cells cultured in serum-containing medium do not require an adaptation phase when transitioning to serum-free MSC NutriStem® XF Medium.

PLTMax® Human Platelet Lysate is a growth factor-rich supplement that is a superior alternative to fetal bovine serum (FBS) for cell culture, including human mesenchymal stem cell (MSC) culture. PLTMax® has a proven track record of clinical use. It has been used to grow cells that have been used in hundreds of patients around the world. PLTMax® is used as a manufacturing component in the generation of adult stems cells in clinical trials in North America, Europe, South America, Middle East, Asia and Australia (Phase I to Phase III) in indications including neurology, nephrology, gastrointestinal disease, wound repair and cardiology. 

• Manufactured to reduce lot-to-lot variation
• Reduced supplementation (PLTMax® is used at half the concentration of FBS)
• Contains more than 100 growth factors and proteins
• Enhances genetic stability in stem cell cultures
• Used in more than 30 clinical trials worldwide

PLTGold® Human Platelet Lysate is a xeno-free, animal serum-free product derived from human platelets. PLTGold® contains all the growth factors and proteins necessary for cell growth, but with reduced turbidity and no clot formation. PLTGold® is the next generation of hPLs which does not require the use of heparin in the manufacturing process. 
 

• Heparin-free and no clot information
• Effective with MSCs and other primary cells (includes: Mesenchymal Stem/Stromal Cells (graph), Hematopoietic Stem Cells, iPSC and iPSC-derived cells, Embryonic Stem Cells, Fibroblasts, Endothelial Cells, Tumor Cells)
• Cost-effective alternative to FBS (stable supply)
• Provides an optimal environment for cell culture and drug discovery