What we do for people with cancer
Adaptimmune is committed to designing and delivering cell therapies to transform the lives of people living with cancer. We have reported clinical responses in multiple solid tumors with our engineered T- cell therapies (called SPEAR T-cells), and we have a deep preclinical pipeline of additional cell therapy products and approaches to enable us to deliver on our mission. We are world leaders with proprietary technology that enables us to engineer T-cell receptors (TCRs) to target tumors. We precisely tune these receptors to attack specific solid tumors, which has led to deep and durable clinical responses in a range of indications. TCRs recognize proteins that are presented on the cell surface in the antigen presentation machinery called human leukocyte antigen (HLA). The current clinical pipeline is restricted to patients who are HLA-02 positive. Our lead program targets a cancer antigen called MAGE-A4, which is expressed on a broad range of solid tumors. We have reported clinical responses in synovial sarcoma, lung, head and neck, and gastroesophageal cancers with our MAGE-A4 targeted SPEAR T-cells. We intend to file our first BLA for afamitresgene autoleucel, our first therapy targeting MAGE-A4, in 2022 using the data from the Phase 2 trial SPEARHEAD-1. We will present initial data about SPEARHEAD-1 at this year’s 2021 ASCO Annual Meeting. We are also applying TCR engineering and enhancement expertise to developing new cell therapy products, including next-generation SPEAR T-cells, TCRs targeted to additional HLA types, HLA independent TCRs (HiTs), and next-generation tumor infiltrating lymphocytes (TILs). Our deep preclinical pipeline of products is designed to reach more cancer targets, broader patient populations, and achieve deeper and more durable responses. We are also developing an “off-the-shelf” or allogeneic cell therapy platform, which would make our therapies available “on demand” for patients who need them.
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